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Exclusive: Doctors need a safer way to drill into the skull. This startup just raised funding to deliver it.


Casey Grage is founder and CEO of Hubly Surgical.
Stefen Pompée

Casey Grage wants to change the way doctors drill holes into the skull — and armed with fresh funding, the neurotechnology startup founder is working toward launching her product to do just that and tapping research partners to get it out there.

The CEO of Hubly Surgical has raised $900,000 in an oversubscribed funding round, $300,000 more than she set out to secure in 2021, from backers including Canadian pre-seed investment vehicle First Fund, the round’s lead investor; Texas angel group SWAN Impact Network; and D.C.’s Halcyon Fund, which made a $50,000 investment.

This round brings Hubly’s lifetime funding to more than $1.3 million, following $300,000 from San Francisco’s Alchemist Accelerator and angel investors in early 2020, and another $140,000 in nondilutive capital from grants and pitch competitions.

“Boring into a person’s skull with a hand-crank drill is fraught with potential problems and adverse events," Grage said in an email. "Residents simply do the best they can with the tools and training they’re given today. Why not make the process as simple as it can be?”

The Hubly Electric Drilling (HED) system aims to enable doctors to more safely and effectively drill holes into the skull without damaging underlying tissue. That process is necessary in numerous instances, including for a condition called hydrocephalus, in which spinal fluid builds up or doesn’t absorb properly. It can happen in cases of traumatic brain injury, hemorrhage, aneurysm or stroke, among others — and can lead to brain damage or death if untreated. Addressing it requires drilling holes into the skull for a tube to drain the fluid. But the current procedure uses “antiquated” tools and can be “unnecessarily dangerous,” Grage said.

The Hubly Electric Drilling system, pictured here, aims to enable doctors to more safely and effectively drill holes into the skull.
Tyler Panian

Hubly’s charge: improve quality of care and outcomes with the company’s electric drill. The new financing positions its five-person team to submit its application to the Food and Drug Administration for clearance. Hubly is working with Lisle, Illinois-based medical device design and development firm Ontogen Medtech to get it done.

The company is also looking for research partners to run cadaver labs, which would help establish standard operating and training procedures, and for clinical trials, which would aim “to show how the HED System can improve patient outcomes compared to today’s standard hand-crank drill as well as the extent physicians find the HED System easier to use,” Grage said. Hubly already counts Northwestern Medicine of Chicago and UMass Memorial Health of Worcester, Massachusetts, as research partners.

Also on the to-do list: hire a vice president of sales and marketing, and manufacture products ahead of landing that regulatory green light. Grage is shooting to submit that application by the end of the first quarter of 2022 and, per that timeline, would expect a response by the third quarter.

Hubly sees Level 1 trauma centers as well as community hospitals, rural clinics and ambulatory care sites as its future customers. But, Grage said, the company will first target urban teaching hospitals with large neurosurgery residency programs. The goal is to generate revenue from hospitals, and for those facilities to be “entirely reimbursed by insurance,” she said.

“We're starting off with our first goal of dramatically improving patient outcomes for this procedure while reducing dependency on operating rooms and cutting down on costs,” Grage said, adding that Hubly’s device could have other applications going forward.

Casey Grage, who took Hubly through Halcyon's incubator, continues to work out of the organization's Georgetown space.
Joanne S. Lawton

Hubly, which also has an office in Chicago, previously went through the Halcyon incubator, the nonprofit’s flagship residency program in Georgetown, where Grage maintains office space. The investment in Hubly from Halcyon’s new fund, which Halcyon has not formally announced the existence of, comes soon after it also backed Arlington’s OxiWear, also an incubator alum — and a medical device company. We have reached out to Halcyon for comment and will update this post as we hear back.

Grage, who remains based in her native Fairfax County and holds a bachelor's in neuroscience from Northwestern University, started Hubly after taking a medical device entrepreneurship class at Northwestern's Kellogg School of Management. In that class, she met Dr. Amit Ayer, a neurosurgeon at the university’s medical school who was working toward his MBA. He became her co-founder and together, they invented the HED System.

“I’ve always been passionate about neurology because, like many, I have a long family history of Alzheimer’s and Parkinson’s diseases,” Grage said, adding that after working in a neurodegenerative research lab, she pivoted from her plan to pursue a career in neuroscientific research. “I decided I wanted to be closer to patient outcomes. I wanted a hand in both creating life-saving tech and aiding in the adoption of that tech into patient's lives,” she said.

Grage, age 22 — and one of our 25 Under 25 honorees of 2021 — previously worked as a software engineer at JPMorgan & Chase Co.


Click through the gallery below to see the rest of this year's 25 Under 25 class.


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