“The year of validation.”
That’s how Cliff Holekamp, co-founder and general partner of St. Louis venture capital firm Cultivation Capital, sums up 2021.
It’s a descriptor given to St. Louis’ entrepreneurial economy thanks to a year marked with several significant exits, including two of its most prominent startups becoming public companies. For Holekamp and others who have been deeply involved in building out St. Louis’ startup sector in the past decade, the string of exits in 2021 offers proof their work is paying dividends.
“Early on, there were some people that were skeptical if St. Louis could ever get critical mass with a true entrepreneurial economy. I don’t think anybody questions that anymore. And 2021 is a big reason why,” Holekamp said.
The biggest St. Louis startup exits in 2021 involved Nerdy (NYSE: NRDY), the parent company of Clayton-based online learning company Varsity Tutors, and food technology firm Benson Hill (NYSE: BHIL) — both arguably the region’s highest-profile startups within the past decade — becoming public companies through mergers with special purpose acquisition companies (SPAC). The SPAC deals valued each company at more than $1 billion, making both so-called “unicorns.”
The exits of Benson Hill and Nerdy also highlighted the role of local institutions and investors in the development of each company.
In the case of Nerdy, its exit put a spotlight on Washington University. Nerdy founder, Chairman and CEO Chuck Cohn launched the company in 2007 as a student at WashU after having difficulty finding a tutor for one of his courses. Meanwhile, Benson Hill’s deal notched a win for several local investors, with the company receiving instrumental funding and support in its early days from BioSTL and Missouri Technology Corp. and later backing from venture capital firms iSelect Fund, Cultivation Capital and Lewis & Clark Ventures, among others.
In addition to the exits of Benson Hill and Nerdy, 2021 also included several acquisitions of St. Louis startups. That’s come amid a red-hot, record-setting global M&A market that has included more than $5 trillion worth of deals in 2021.
2021 Startup Exits
Online education firm Nerdy in September closed its business combination with a special purpose acquisition company Star Peak Corp II to go public. Nerdy and TPG Pace Tech Opportunities in January announced their proposed deal, which valued Varsity Tutors’ parent company with a $1.7 billion market capitalization.
Nerdy
In September, food technology firm Benson Hill completed a merger with combination with special purpose acquisition company Star Peak Corp II to become a public company. Evanston, Illinois-based Star Peak and Benson Hill in May announced their $2 billion deal, which they said would value Benson Hill at about $1.35 billion.
Benson Hill
In January, Austin-based Upland Software Inc. (Nasdaq: UPLD) said it had purchased St. Louis software company Second Street for $25.4 million in cash at closing and a $5 million cash holdback payable in 12 months, subject to indemnification claims. Founded in 2007, Second Street provides audience engagement software for local media companies. Pictured is Second Street co-founder Doug Villhard.
Washington University
Irving, Texas-based Lightbeam Health Solutions Inc. has purchased St. Louis startup CareSignal in a deal announced in November. Founded in 2015, CareSignal (formerly Epharmix) has developed a remote patient monitoring platform used by health systems, payers and physician groups. Blake Marggraff, co-founder and CEO of CareSignal, is pictured.
Wesley Law
Swansea, Illinois-based startup OneSpace, which provides e-commerce technology and services for consumer brands, in September announced it had been bought by London-based Ascential (LSE: ASCL.L). OneSpace’s offers e-commerce search data, product management and content optimization technology and services to consumer brands. It has joined Ascential’s Digital Commerce business unit, the London firm’s largest business division by annual revenue. OneSpace founder and CEO Stephanie Leffler is pictured.
St. Louis-based technology startup TopOPPS, which provides sales pipeline management and forecasting software, was acquired by San Jose software firm Xactly. Financial terms of the deal, announced in March, were not disclosed. TopOpps founder Jim Eberlin is pictured. Software firm Xactly Corp Jim Eberlin of TopOPPS
Dilip Vishwanat | SLBJ
Accrue Technologies was acquired by Nashville-based software development firm Core10. Founded in 2020, Accrue has developed a lending and banking platform for community banks and credit unions. Its founder, Chris Sommers, is photographed. Chris Sommers, founder of Accrue Technologies
Chris Sommers
St. Louis startup Radiologics, which provides software and services for imaging-based clinical trial workflows, has joined forces with a fast-growing company in the Twin Cities. Minneapolis-based Flywheel in September said acquired Radiologics. Pictured in the Flywheel team.
Flywheel
Chesterfield-based Aspire, which provides business management software to landscape contractors, was acquired by software firm ServiceTitan. Kevin Kehoe (left) and Mark Tipton, founders of Aspire Software, are pictured.
Aspire Software
NielsenIQ purchased Label Insight, a Chicago firm that has a database of consumer product information and that has ties St. Louis. While based in Chicago, Label Insight was headquartered in St. Louis for several years and was backed by multiple local investors. It has continued to maintain operations in St. Louis. Todd Morris, CEO of Label Insight, is pictured.
Label Insight photo
Fenton-based transportation and relocation company UniGroup acquired St. Louis technology startup Handled. Founded in 2019, Handled created an app-based platform it describes as a “personal concierge” for local moving, relocation and home services. Pictured in Jason Mills
UniGroup
SCROLL THROUGH THE GALLERY ABOVE TO SEE WHICH ST. LOUIS STARTUPS HAD EXITS IN 2021
In a sign of momentum for St. Louis’ entrepreneurial ecosystem, two local startup sales involved entrepreneurs who have already had exits with other local companies. Jim Eberlin's startup TopOPPS, which provides sales pipeline management and forecasting software, sold to San Jose-based software firm Xactly Corp. That marked a “hat trick” for Eberlin, who also experienced exits with his St. Louis-born startups Gainsight and Planful. The sale of e-commerce startup OneSpace to London-based Ascential gave Stephanie Leffler her second exit. In 2006, she sold another St. Louis e-commerce startup, MonsterCommerce.
Exits aren't the only indicator that St. Louis' entrepreneurial ecosystem had a robust 2021.
It also is set to be a strong — and potentially record-setting — year for venture capital investment in St. Louis startups. Through the first three quarters of the year, St. Louis startups raised $374.9 across 44 deals, according to data from PitchBook and the National Venture Capital Association. Local firms raised $256.8 million for the quarter ended Sept. 30, the highest total of funding in a single quarter since local firms raised $302.7 million in the third quarter of 2018.